MCQ Multiple Choice Question of Pharmaceutical Organic chemistry

MCQ Multiple Choice Question of Pharmaceutical Organic chemistry

1. The analgesic action of aspirin is removed, if

a. Carboxyl group is removed
b. Acetoxy group is removed
c. Carboxyl group is not attached on ortho position
d. All of the above

2. Caffeine is presented as a/an

a. Purine derivative
b. Pyrimidine derivative
c. Imidazole derivative
d. both b and c

3. A group that can donate an electron pair is

a. Bronsted acid
b. Bronsted base
c. Lewis acid
d. Lewis base

4. Which one of most acidic among the following

a. Propynoic acid

b. Propenoic acid 

c. Propanoic acid

5. Hendersen-Hasselbalch equation is represented by

a. Ka = [A][H+]/[HA]
b. pKa + pKb = 14
c. pKa = pH + log [HA]/[A-]
d. both a and c

6. Which of the following is through space-effects on polarizability due to electronegativity differences?

a. Field effect
b. Resonance effect
c. Inductive Effect
d. Polarizability

7. Which of the following is the ease of distortion of the electron cloud?

a. Field effect
b. Inductive Effect
c. Resonance effect
d. Polarizability

8. Which of the following occurs as a result of electronegativity differences?

a. Field effect
b. Inductive Effect 

c. Resonance effect
d. None of the above

9. Which of the following involves the actual movement of electrons through a pie-bond system?

a. Field effect
b. Inductive Effect 

c. Resonance effect
d. None of the above

10. The movement of electrons through a conjugated system allows for charges to be dispersed over several atoms. This phenomenon is

a. Localization
b. Delocalization
c. Polarization
d. Depolarization

11. Which of the following is less influenced by distance?

a. Field effect
b. Inductive Effect
c. Resonance effect
d. both a and c

12. Which of the following is a carbonyl based group?

a. esters
b. nitro-
c. alcohols
d. ethers

13. Which of the following shows electron withdrawing groups?

a. phenyl
b. ethers
c. amines
d. alkyl groups

14. Which of the following shows electron donating group?

a. amides
b. esters
c. ketones
d. amines

15. Which of the following has minimum pKa value or maximum acidic strength?

a. imide
b. sulphonamide
c. N-arylsulfonamide
d. sulfonimide

16. Sigma-bonding electrons, especially those from C-H bonds can be donated in a process known as

a. conjugation 

b. Hyperconjugation
c. polarization
d. depolarization

17. Which of the following has neutral pKa value?

a. Water
b. Ether
c. Amide
d. All of the above

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